One week in the lives of over a dozen people involved in the magazine and entertainment business of New York City. The central characters include Italian designer Lorenzo Mancini who learns that he's dying from cancer and decides to get his affairs in order with his wife Irine and his business partner Guido. Lorenzo's son Mario is a recording promoter who's latest client is hip-hop rapper J.B.. Roberta is a designer hard-pressed to fill out a latest dress design for the next Broadway show her group is putting on. Other characters are Jamie (Jeff Goldblum), a crafty agent whose latest client, Camille (Leslie Mann) finds success but affects their relationship in ways he never planned and fails to deal with. Arrianne (Estella Warren) a model, Leese Hotton (Mariel Hemingway) is a has-been model/actress trying to make a comeback into the spotlight; Janice Crawford (Joanne Baron) is a wealthy publisher and control freak whose problems escalate with the arrival of her estranged teenage daughter Halley (Michelle Williams) whom Janice abandoned her and everything else for her career years ago.

Spring Street and Crosby Street, Manhattan.

Anthony's Apartment, 75 Spring Street and Crosby Street, Manhattan.

Jeffrey Store, 449 West 14th Street and Washington Street, Manhattan.

Fulton Ferry Pier (Near Brooklyn Bridge) Brooklyn.

Washington Street and West 14th Street, Manhattan.

9th Avenue and Little West 12th Street, Manhattan.

Times Square (Broadway, 7th Avenue, West 42nd and 47th Streets) Manhattan.