Two years have passed for Peter Parker (Tobey Maguire), established in his role as college student...and as a crime fighter. He can't keep up at school, pay his rent, or make amends with his estranged best friend Harry, who wants Spider-Man dead. Mary Jane (Kirsten Dunst) is more skeptical than ever of the man in her life. Peter's idol, a renowned scientist named Otto Octavius, who resurfaces as Doctor Octopus following a failed fusion experiment. Peter, at times noticing he's losing some of his powers, and feeling the effects of the stress in his personal life, realizes he must decide btw being who he once was or retaining his secret identity to stop Doc Ock and save New York City.

Joe's Pizza, 233 Bleecker Street and Carmine Street, Manhattan.

Columbia University, Broadway and 116th Street, Manhattan.

Peter Parker's Apartment, 187 Chrystie Street and Stanton Street, Manhattan.

Dr Octavius' Lab, 32 2nd Avenue and East 2nd Street, Manhattan.

Centre Street and Chambers Street, Financial, Manhattan.

Riverside Church, 490 Riverside Drive and West 120th Street, Manhattan.   Riverside Church The Riverside Church in the City of New York is an interdenominational (American Baptist and United Church of Christ) church in New York City, famous not only for its elaborate Gothic architecture—which includes the world's largest tuned carillon bell—but also as a center for the promotion of progressive causes. It is located in Harlem btw Riverside Drive and Claremont Avenue and btw 120th Street and 122nd Street. The tallest church in the United States and the 26th tallest in the world, it was described by The New York Times in 2008 as "a stronghold of activism and political debate throughout its 75-year history ... influential on the nation’s religious and political landscapes."[1] The church received New York City Landmark status in 2000.