Los Angeles commercials director Max Carlyle (Wesley Snipes) visits his friend, artist Charlie (Robert Downey Jr.), who was diagnosed with AIDS in New York. There he meets Karen (Nastassja Kinski), they are attracted to each other and after they meet later that day at the concert, they have a passionate night. Then he returns home to L.A. to his family and wife Mimi (Ming-Na). A year later Max returns to New York again to visit Charlie who is now dying, and there he meets Karen again, who is married to Charlie's brother Vernon (Kyle MacLachlan).

Millennium Broadway Hotel, 145 West 44th Street and 6 Avenue, Manhattan.

Broadway and West 44th Street, Manhattan.   Times Square is a major commercial intersection, at the junction of Broadway and Seventh Avenue and stretching from West 42nd to West 47th Street. Webcam: Times Square Live Webcam

Park Avenue (near to Grand Central Terminal) Manhattan.

20 Exchange Place and William Street, Manhattan.   20 Exchange Place took the place of the fake New York Memorial Hospital.

Mercer Street and Spring Street, Manhattan.