In September 2010, the American Cinematheque at Aero theatre in Los Angeles, Desperately Seeking Susan was shown again on the big screen for the first time in 25 years. Several members of the original cast including producers Sarah Pillsbury and Midge Sandford were present at the event to discussion the film and their experiences whilst making it.

(Some of the original cast members in 2010)

Directed by Susan Seidelman, the main plot of the film followed Roberta played by Rosanna Arquette, an unfulfilled suburban housewife living in Fort Lee, New Jersey who became fascinated with a woman she only knew about by reading messages to and from her in the personals section of a New York City tabloid. This fascination reached a peak when one such ad with the headline "Desperately Seeking Susan" proposed a rendezvous in Battery Park with the man who regularly searched for her. Roberta takes a trip to Battery Park too, and finally gets a glimpse of the woman played by Madonna, and in a series of events involving mistaken identity, amnesia, and other farcical elements, Roberta goes from voyeur to participant in an Alice in Wonderland–style plot, ostensibly motivated by the search for a pair of stolen Egyptian earrings. With both of them trying to locate Roberta, her husband becomes involved with the wild Susan.

Special Report (Day 3) looks back at the Bleecker Street Cinema where the character of Dez worked.